Publications

Main Content

2022 Publications

  • Omoto ACM, do Carmo JM, Nelson B, Aitken N, Dai X, Moak S, Flynn E, Wang Z, Mouton AJ, Li X, Hall JE, da Silva AA. Central Nervous System Actions of Leptin Improve Cardiac Function After Ischemia-Reperfusion: Roles of Sympathetic Innervation and Sex Differences. J Am Heart Assoc.2022 Nov;11(21):e027081. doi: 10.1161/JAHA.122.027081. Epub 2022 Oct 27. PMID: 3630066
  • Eirin A, Chade AR. Cardiac epigenetic changes in VEGF signaling genes associates with myocardial microvascular rarefaction in experimental chronic kidney disease. Am J Physiol Heart Circ Physiol. 2022 Nov 11. doi: 10.1152/ajpheart.00522.2022. Online ahead of print.
  • Chade AR, Eirin A. Cardiac micro-RNA and transcriptomic profile of a novel swine model of chronic kidney disease and left ventricular diastolic dysfunction. Am J Physiol Heart Circ Physiol. 2022 Oct 1;323(4):H659-H669. doi: 10.1152/ajpheart.00333.2022. Epub 2022 Aug 26. PMID:36018756.
  • Nemeth Z, Hildebrandt E, Parsa N, Fleming AB, Wasson R, Pittman K, Bell X, Granger JP, Ryan MJ, Drummond HA. Epithelial Sodium Channels in Macrophage Migration and Polarization: Role of Proinflammatory Cytokines TNFα and IFNγ. Am J Physiol Regul Integr Comp Physiol. 2022 Oct 3. doi: 10.1152/ajpregu.00207.2022. Online ahead of print. PMID:36189990.
  • Kaur H, Rawat D, Poria P, Sharma U, Gibert Y, Ethayathulla AS, Dumée LF, Sharma RS, Mishra V. Ecotoxic effects of microplastics and contaminated microplastics - Emerging evidence and perspective. Sci Total Environ. 2022 Oct 1;841:156593. doi: 10.1016/j.scitotenv.2022.156593. Epub 2022 Jun 9. PMID:35690218.
  • Badmus OO, Hillhouse SA, Anderson CD, Hinds TD, Stec DE. Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways. Clin Sci (Lond). 2022 Sep 30;136(18):1347-1366. doi: 10.1042/CS20220572.PMID:36148775.
  • Jones-Muhammad M, Shao Q, Warrington JP. Increased seizure sensitivity in pregnant mice with genetic knockdown of acid sensing ion channel 2a is associated with impaired hippocampal inflammatory response. Front Physiol. 2022 Sep 14;13:983506. doi: 10.3389/fphys.2022.983506. eCollection 2022. PMID: 36187797.
  • Ashraf UM, Hall DL, Campbell N, Waller JP, Rawls AZ, Solise D, Cockrell K, Bidwell GL 3rd, Romero DG, Ojeda NB, LaMarca B, Alexander BT. Inhibition of the AT1R agonistic autoantibody in a rat model of preeclampsia improves fetal growth in late gestation. Am J Physiol Regul Integr Comp Physiol. 2022 Sep 19. doi: 10.1152/ajpregu.00122.2022. Online ahead of print. PMID:36121142.
  • Clemmer JS, Pruett WA. Modeling the physiological roles of the heart and kidney in heart failure with preserved ejection fraction during baroreflex activation therapy. Am J Physiol Heart Circ Physiol. 2022 Sep 1;323(3):H597-H607. doi: 10.1152/ajpheart.00329.2022. Epub 2022 Aug 19. PMID:35984764.
  • Chade AR, Bidwell GL 3rd.  Novel Drug Delivery Technologies and Targets for Renal Disease. Hypertension. 2022 Sep;79(9):1937-1948. doi: 10.1161/HYPERTENSIONAHA.122.17944. Epub 2022 Jun 2. PMID: 35652363. 
  • Smith AM, Welch BA, Harris KK, Garrett MR, Grayson BE. Nutrient composition influences the gut microbiota in chronic thoracic spinal cord injured rats. Physiol Genomics. 2022 Aug 29. doi: 10.1152/physiolgenomics.00037.2022. Online ahead of print. PMID: 36036458.
  • Pruett JE, Everman SJ, Hoang NH, Salau F, Taylor LC, Edwards KS, Hosler JP, Huffman AM, Romero DG, Yanes Cardozo LL. Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition. Biol Sex Differ. 2022 Aug 19;13(1):45. doi:10.1186/s13293-022-00455-x. PMID: 35986388.
  • Shrestha AP, Saravanakumar A, Konadu B, Madireddy S, Gibert Y, Vaithianathan T. Embryonic Hyperglycemia Delays the Development of Retinal Synapses in a Zebrafish Model. Int J Mol Sci. 2022 Aug 26;23(17):9693. doi: 10.3390/ijms23179693.PMID:36077087.
  • Stapel JR, Speed JS, Clemmer JS. Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension. Can J Physiol Pharmacol. 2022 Aug 1;100(8):828-833. doi: 10.1139/cjpp-2022-0132. Epub 2022 Jun 3. PMID: 35658576.
  • Taylor EB, George EM. Animal Models of Preeclampsia: Mechanistic Insights and Promising Therapeutics. Endocrinology. 2022 Aug 1;163(8):bqac096. doi: 10.1210/endocr/bqac096. PMID:35772781.
  • Taylor EB. Casting a wide NET: an update on uncontrolled NETosis in response to COVID-19 infection. Clin Sci (Lond). 2022 Jul 15;136(13):1047-1052. doi: 10.1042/CS20220039. PMID: 3579184.
  • Weingarten EA, Zee PC, Jackson CR. Microbial Communities in Saltpan Sediments Show Tolerance to Mars Analog Conditions, but Susceptibility to Chloride and Perchlorate Toxicity. Astrobiology. 2022 Jul;22(7):838-850. doi: 10.1089/ast.2021.0132. Epub 2022 Jun 22. PMID:35731161.
  • Ashraf S, Taegtmeyer H, Harmancey R. Prolonged cardiac NR4A2 activation causes dilated cardiomyopathy in mice. Basic Res Cardiol. 2022 Jul 1;117(1):33. doi: 10.1007/s00395-022-00942-7.
  • Nemeth Z, Granger JP, Ryan MJ, Drummond HA. Is there a role of proinflammatory cytokines on degenerin-mediated cerebrovascular function in preeclampsia? Physiol Rep. 2022 Jul;10(13):e15376. doi: 10.14814/phy2.15376.
  • Williams JM, Murphy SR, Wu W, Border JJ, Fan F, Roman RJ. Renoprotective effects of empagliflozin in type 1 and type 2 models of diabetic nephropathy superimposed with hypertension. Geroscience. 2022 Jun 29. doi: 10.1007/s11357-022-00610-7. Online ahead of print.
  • Heather LC, Hafstad AD, Halade GV, Harmancey R, Mellor KM, Mishra PK, Mulvihill EE, Nabben M, Nakamura M, Rider OJ, Ruiz M, Wende AR, Ussher JR. Guidelines on models of diabetic heart disease. Am J Physiol Heart Circ Physiol. 2022 Jul 1;323(1):H176-H200. doi: 10.1152/ajpheart.00058.2022. Epub 2022 Jun 3.
  • He X, Zeng H, Cantrell AC, Williams QA, Chen JX. Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure. J Cell Physiol. 2022 May 27. doi: 10.1002/jcp.30790. Online ahead of print.
  • Li X, Flynn ER, do Carmo JM, Wang Z, da Silva AA, Mouton AJ, Omoto ACM, Hall ME, Hall JE. Direct Cardiac Actions of Sodium-Glucose Cotransporter 2 Inhibition Improve Mitochondrial Function and Attenuate Oxidative Stress in Pressure Overload-Induced Heart Failure. Front Cardiovasc Med. 2022 May 12;9:859253. doi: 10.3389/fcvm.2022.859253. eCollection 2022. PMID:3564708.
  • Stec DE, Tiribelli C, Badmus OO, Hinds TD Jr. Novel Function for Bilirubin as a Metabolic Signaling Molecule: Implications for Kidney Diseases. Kidney360. 2022 Mar 25;3(5):945-953. doi: 10.34067/KID.0000062022. eCollection 2022 May 26. PMID:36128497.
  • Fang X, Zhang J, Roman RJ, Fan F. From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia? Geroscience. 2022 May 19. doi: 10.1007/s11357-022-00591-7. Online ahead of print.
  • Wang Z, do Carmo JM, da Silva AA, Fu Y, Jaynes LT, Sears J, Li X, Mouton AJ, Omoto ACM, Xu BP, Hall JE. Transient receptor potential cation channel 6 (TRPC6) deficiency leads to increased body weight and metabolic dysfunction. Am J Physiol Regul Integr Comp Physiol. 2022; doi: 10.1152/ajpregu.00097.2021. Online ahead of print.
  • Monroe JD, Fraher D, Huang Z, Mellett NA, Meikle PJ, Sinclair AJ, Lirett ST, Maihle NJ, Gong Z, Gibert Y. Indentification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular cardinoma in zebrafish. Cancer Metab. 2022 Apr 4;10(1):7.doi: 10.1186/s40170-022-00283-y.
  • He X, Cantrell AC, Williams QA, Chen JX, Zeng H. TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury. Physiol Rep. 2022 Apr;10(8):e15234. doi: 10.14814/phy2.15234. PMCID: PMC9020173. 
  • Clemmer JS, Hillegass WB, Taylor EB. Antihypertensive effects of immunosuppressive therapy in autoimmune disease. J Hum Hypertens. 2022 Apr 8. doi: 10.1038/s41371-022-00682-0. Online ahead of print. PMID: 35396536
  • Shawky NM, Dalmasso C, Ojeda NB, Zuchowski Y, Stachenfeld N, Alexander BT, Reckelhoff JF. Consequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II. J Hypertens. 2022 Apr 1;40(4):712-722. doi: 10.1097/HJH.0000000000003067.
  • da Silva AA, Moak SP, Dai X, Borges GC, Omoto ACM, Wang Z, Li X, Mouton AJ, Hall JE, do Carmo JM. Parental obesity alters offspring blood pressure regulation and cardiovascular responses to stress: role of P2X7R and sex differences. Am J Physiol Regul Integr Comp Physiol. 2022 Mar 23. doi: 10.1152/ajpregu.00300.2021. Online ahead of print.
  • Irazabal MV, Chade AR, Eirin A.Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs. Clin Sci (Lond). 2022 Mar 18;136(5):345-360. doi: 10.1042/CS20210512.
  • McClung JA, Levy L, Garcia V, Stec DE, Peterson SJ, Abraham NG. Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications.  Pharmacol Ther. 2022 Mar;231:107975. doi: 10.1016/j.pharmthera.2021.107975. Epub 2021 Sep 6. PMCID: PMC8958338
  • Lu Y, Stec DE, Liu R, Ryan MJ, Drummond HA. bENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole. Am J Physiol Renal Physiol. 2022 Mar 14. doi: 10.1152/ajprenal.00003.2022. Online ahead of print.
  • Coniglio AC, Segar MW, Loungani RS, Savla JJ, Grodin JL, Fox ER, Garg S, de Lemos JA, Berry JD, Drazner MH, Shah S, Hall ME, Shah A, Khan SS, Mentz RJ, Pandey A. Transthyretin V142I Genetic Variant and Cardiac Remodeling, Injury, and Heart Failure Risk in Black Adults. JACC Heart Fail. 2022 Feb;10(2):129-138. doi: 10.1016/j.jchf.2021.09.006. Epub 2021 Dec 8.
  • Bakrania BA, Palei AC, Bhattarai U, Chen Y, Granger JP, Shahul S. Sustained Elevated Circulating Activin A Impairs Global Longitudinal Strain in Pregnant Rats: A Potential Mechanism for Preeclampsia-Related Cardiac Dysfunction. Cells. 2022 Feb; 11(4): 742. Published online 2022 Feb 21. doi: 10.3390/cells11040742.
  • Thomas DT, DelCimmuto NR, Flack KD, Stec DE, Hinds TD Jr. Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin. Antioxidants (Basel). 2022 Feb; 11(2): 179. Published online 2022 Jan 18. doi: 10.3390/antiox11020179.
  • Zhang H, Roman RJ, Fan F. Hippocampus is more susceptible to hypoxic injury: has the Rosetta Stone of regional variation in neurovascular coupling been deciphered? Geroscience. 2022 Feb;44(1):127-130. doi: 10.1007/s11357-021-00449-4. Epub 2021 Aug 28.
  • Poudel B, Shields CA, Ekperikpe US, Brown AK, Travis OK, Maury JC, Fitzgerald S, Smith SV, Cornelius DC, Williams JM. The SSLepR mutant rat represents a novel model to study obesity-induced renal injury before puberty. Am J Physiol Regul Integr Comp Physiol. 2022 Apr 1;322(4):R299-R308. doi: 10.1152/ajpregu.00179.2021. Epub 2022 Feb 2.
  • Topaloglu AK, Simsek E, Kocher MA, Mammadova J, Bober E, Kotan LD, Turan I, Celiloglu C, Gurbuz F, Yuksel B, Good DJ. Inactivating NHLBH2 variants cause idiopathic hypogonadotropic hypogonadism and obesity in humans. Hum Genet. 2022 Feb;141(2):295-304. doi: 10.1007/s00439-021-02422-9.
  • Gonzalez-Fernandez E, Fan L, Wang S, Liu Y, Gao W, Thomas KN, Fan F, Roman RJ. The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases. Physiol Genomics. 2022 Feb 1;54(2):58-70. doi: 10.1152/physiolgenomics.00119.2021. Epub 2021 Dec 3.
  • Wang S, Jiao F, Border JJ, Fang X, Crumpler RF, Liu Y, Zhang H, Jefferson J, Guo Y, Elliott PS, Thomas KN, Strong LB, Urvina AH, Zheng B, Rijal A, Smith SV, Yu H, Roman RJ, Fan F. Luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, reverses cerebrovascular dysfunction and cognitive impairments in 18-mo-old diabetic animals. Am J Physiol Heart Circ Physiol. 2022 Feb 1;322(2):H246-H259. doi: 10.1152/ajpheart.00438.2021. Epub 2021 Dec 24.
  • Wang Z, Fu Y, do Carmo JM, da Silva AA, Li X, Mouton A, Omoto ACM, Sears J, Hall JE. Transient receptor potential cation channel 6 contributes to kidney injury induced by diabetes and hypertension. Am J Physiol Renal Physiol. 2022 Jan 1;322(1):F76-F88. doi: 10.1152/ajprenal.00296.2021. Epub 2021 Dec 6.
  • Hall ME, Hall JE. Sex Differences in Hypertension: Related to Genes, Jean Sizes, and Salt Sensitivity? Hypertension. 2022 Jan;79(1):47-49. doi: 10.1161/HYPERTENSIONAHA.121.18425. Epub 2021 Dec 8.
  • Ou Y, Clifton BA, Li J, Sandlin D, Li N, Wu L, Zhang C, Chen T, Huang J, Yu Y, Allison J, Fan F, Roman RJ, Shaffery J, Zhou W, Pang Y, Zhu H. Traumatic brain injury induced by exposure to blast overpressure via ear canal. Neural Regen Res. 2022 Jan;17(1):115-121. doi: 10.4103/1673-5374.314311.
  • Santos CDSE, Welch BA, Edwards SR, Harris KK, Duncan BC, Himel AR, Grayson BE. Immune and metabolic biomarkers in a rodent model of spinal cord contusion. Global Spine J. 2022; Jan;12:110-120. doi: 10.1177/2192568220950337.